Certain medical conditions may prohibit the use of Clomid. Clomid works by tricking the brain into thinking that your estrogen levels are unusually low. Since estrogen levels appear to be low, your body thinks there are no growing follicles; and responds by releasing hormone that signals your pituitary gland to produce more FSH follicle stimulating hormone and LH Luteinizing hormone. The higher levels of FSH stimulate the ovaries, and the higher levels of LH eventually trigger ovulation.
As the follicles on the ovaries grow, they release estrogen. The increase in estrogen signals the brain to slow down the production of FSH, which in turn slows down the stimulation of the ovaries.
Clomid should not be used for more than six cycles in your life due to the slightly increased risk of ovarian cancer if used for more than 12 cycles.
You should ideally take the Clomid at the same time every day, and some say that taking the pill before bed can help you sleep through some of the side effects. Some do better if they take the pill in the morning. Ovulation typically occurs 5 — 10 days after taking the last Clomid pill. During ovulation, the brain's pituitary gland releases two hormones: follicle stimulating hormone FSH and luteinizing hormone LH.
Together, these hormones are known as gonadotropins. FSH acts as a 'messenger' sent by the pituitary gland to stimulate the development of follicles in the ovaries, each of which will contain one egg. LH is responsible for triggering the release of the egg ovulation. During the first half of the menstrual cycle, the ovarian follicles produce the hormone estradiol, which stimulates the growth of the uterine lining endometrium and the production of the watery 'raw egg white' cervical mucus that functions to help the sperm as it swims up through the uterus to the fallopian tubes.
After approximately two weeks, the pituitary releases a surge of LH hormone, triggering ovulation. At this stage, the follicle, now known as the corpus luteum, begins to produce the hormone progesterone, which serves to thicken the uterine lining to prepare for possible pregnancy. Two weeks after ovulation, if a pregnancy has not occurred, the corpus luteum stops progesterone production, the endometrium sloughs off and menstrual bleeding occurs.
Any number of conditions can hamper the body's ability to ovulate effectively. One of the primary ways to address this challenge is with medications that stimulate the ovarian follicles to produce multiple eggs in one cycle.
Clomiphene is a synthetic chemical, taken orally, that binds to estrogen receptors in the brain and causes pituitary FSH levels to rise see below.
Gonadotropins are identical to human protein hormones FSH and LH and, given by injection, bypass the pituitary gland and directly stimulate the ovaries. Clomiphene is a long trusted oral medication relied upon for its safety, effectiveness and relatively low cost. Clomiphene is used to treat absent or irregular menstrual cycles ovulation induction , to address a condition called luteal phase defect by increasing progesterone secretion during the second half of the cycle and to make menstrual cycle lengths more predictable, thus improving the timing of intercourse or artificial insemination.
Clomiphene may also be used to enhance ovulation in women who are already ovulating ovulation augmentation. Clomiphene used in conjunction with a medication called Provera may be effective in initiating menstruation and ovulation in women who have no menstrual cycle:.
If ovulation doesn't occur during this initial clomiphene dosage, another course of provera will be prescribed and the dose of clomiphene increased until ovulation occurs. It may be possible to begin another clomiphene cycle immediately or, if residual cysts are present on the ovarian follicles, a 'rest' cycle may be advised before resuming treatment. If ovulation cannot be induced even with a higher dose of clomiphene, this form of treatment will be discontinued, and ovulation induction may be attempted again using a different form of fertility drug letrozole or gonadotropins.
In women that menstruate regularly on their own, clomiphene may be used to help the ovaries to produce more than one mature egg. This is sometimes referred to as "superovulation. If the clomiphene cycle did not produce sufficient egg follicles, it may be possible to begin another cycle immediately; or, if residual cysts are present on the ovarian follicles, a rest cycle may be advised before resuming treatment. Ovulation predictor kits detecting the LH surge may demonstrate false positive results if testing begins near the time of clomiphene citrate administration.
If patients start ovulation predictor kit testing on cycle day 9 or earlier, there is a high probability of obtaining a false positive result. For that reason, we recommend caution in testing too soon. If a patient is not pregnant and menses occurs, the same dose of clomiphene is given after a normal pelvic sonogram.
We usually recommend up to 6 cycles for ovulation induction patients and up to 3 or 4 for ovulation augmentation patients. Older patients may not achieve these rates as their declining egg quality will become a factor. Am i supposed to automatically take the Provera again on the 1st of June? That just doesn't sound right to me.
Please help me understand this. She is not correct on the proper method to do a Clomid ovulation induction cycle. I would recommend that you look up my blog and review how I recommend doing Clomid cycles. I think you will be shocked once you compare it to what your doctor prescribed! First, Clomid cycles should be monitored for three reasons: 1 to see whether you are responding to that dose of Clomid there are five dosages that can be used.
The "autopilot" method of Clomid ovulation induction is not correct and shows that your doctor has a very limited knowledge of this treatment and infertility in general.
I would strongly recommend that you go see a fertility specialist so that you don't waste your time. Many doctors will use a progesterone supplement with Clomid cycles in order to support implantation and the early pregnancy.
Clomid often can induce a luteal phase defect.
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